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1987-10-07
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IN PATIENTS WITH RENAL IMPAIRMENT, MEPROBAMATE DOSAGE SHOULD
BE CAREFULLY ADJUSTED TO AVOID TOXICITY (EXCESSIVE SEDATION,
ENCEPHALOPATHY, AND RESPIRATORY DEPRESSION).
SOME CLINICIANS RECOMMEND THAT THE DOSAGE REGIMEN BE ADJUSTED
BASED ON THE PATIENT'S CREATININE CLEARANCE:
CREATININE
CLEARANCE DOSAGE INTERVAL
(ML/MINUTE)
10-50 9 to 12 hours
<10 12 to 18 hours